Publications – Center for Communicable Disease Dynamics

The role of interspecies recombinations in the evolution of antibiotic resistant pneumococci.

Author(s): D’Aeth JC, van der Linden MPG, McGee L, de Lencastre H, Turner P, Song JH, Lo SW, Gladstone RA, Sá-Leão R, Ko KS, Hanage WP, Breiman RF, Beall B, Bentley SD, Croucher NJ, GPS Consortium.Journal: ElifePMID: 34259624 July 2021

Multidrug-resistant emerge through the modification of core genome loci through short inter-species homologous recombinations and acquisition of gene cassettes. Both…

Modeling the impact of racial and ethnic disparities on COVID-19 epidemic dynamics.

Author(s): Ma KC, Menkir TF, Kissler SM, Grad YH, Lipsitch MJournal: ElifePMID: 34003112 May 2021

The impact of variable infection risk by race and ethnicity on the dynamics of SARS CoV-2 spread is largely unknown.

Estimating SARS-CoV-2 seroprevalence and epidemiological parameters with uncertainty from serological surveys.

Author(s): Larremore DB, Fosdick BK, Bubar KM, Zhang S, Kissler SM, Metcalf CJE, Buckee C, Grad YHJournal: ElifePMID: 33666169 March 2021

Establishing how many people have been infected by SARS-CoV-2 remains an urgent priority for controlling the COVID-19 pandemic. Serological tests…

Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants.

Author(s): Hicks AL, Kissler SM, Mortimer TD, Ma KC, Taiaroa G, Ashcroft M, Williamson DA, Lipsitch M, Grad YHJournal: ElifePMID: 32602459 June 2020

Genotype-based diagnostics for antibiotic resistance represent a promising alternative to empiric therapy, reducing inappropriate antibiotic use. However, because such assays…

A Global lmmunological Observatory to meet a time of pandemics.

Author(s): Mina MJ, Metcalf CJE, McDermott AB, Douek DC, Farrar J, Grenfell BTJournal: ElifePMID: 32510329 June 2020

SARS-CoV-2 presents an unprecedented international challenge, but it will not be the last such threat. Here, we argue that the…

Potential impact of outpatient stewardship interventions on antibiotic exposures of common bacterial pathogens.

Author(s): Tedijanto C, Grad YH, Lipsitch MJournal: ElifePMID: 32022685 February 2020

The relationship between antibiotic stewardship and population levels of antibiotic resistance remains unclear. In order to better understand shifts in…

Previously undetected super-spreading of Mycobacterium tuberculosis revealed by deep sequencing.

Author(s): Lee RS, Proulx JF, McIntosh F, Behr MA, Hanage WPJournal: ElifePMID: 32014110 February 2020

Tuberculosis disproportionately affects the Canadian Inuit. To address this, it is imperative we understand transmission dynamics in this population. We…

RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates.

Author(s): Palace SG, Wang Y, Rubin DH, Welsh MA, Mortimer TD, Cole K, Eyre DW, Walker S, Grad YHJournal: ElifePMID: 32011233 February 2020

Increasing resistance to ceftriaxone, the last antibiotic recommended for empiric gonorrhea treatment, poses an urgent public health threat. However, the…

Mapping imported malaria in Bangladesh using parasite genetic and human mobility data.

Author(s): Chang HH, Wesolowski A, Sinha I, Jacob CG, Mahmud A, Uddin D, Zaman SI, Hossain MA, Faiz MA, Ghose A, Sayeed AA, Rahman MR, Islam A, Karim MJ, Rezwan MK, Shamsuzzaman AKM, Jhora ST, Aktaruzzaman MM, Drury E, Gonçalves S, Kekre M, Dhorda M, Vongpromek R, Miotto O, Engø-Monsen K, Kwiatkowski D, Maude RJ, Buckee CJournal: ElifePMID: 30938289 August 2019

For countries aiming for malaria elimination, travel of infected individuals between endemic areas undermines local interventions. Quantifying parasite importation has…

Response to comment on ‘The distribution of antibiotic use and its association with antibiotic resistance’.

Author(s): Olesen SW, Lipsitch M, Grad YHJournal: ElifePMID: 31050649 August 2019

We are writing to reply to the comment by Pouwels et al., 2019 about our recent study (Olesen et al.,…