Author(s): Hay JA, Kissler SM, Fauver JR, Mack C, Tai CG, Samant RM, Connolly S, Anderson DJ, Khullar G, MacKay M, Patel M, Kelly S, Manhertz A, Eiter I, Salgado D, Baker T, Howard B, Dudley JT, Mason CE, Nair M, Huang Y, DiFiori J, Ho DD, Grubaugh N, Grad YH|Journal: Elife|PMID:36383192| November 2022
The combined impact of immunity and SARS-CoV-2 variants on viral kinetics during infections has been unclear. We characterized 1,280 infections…
Author(s): Magosi LE, Zhang Y, Golubchik T, DeGruttola V, Tchetgen Tchetgen E, Novitsky V, Moore J, Bachanas P, Segolodi T, Lebelonyane R, Pretorius Holme M, Moyo S, Makhema J, Lockman S, Fraser C, Essex MM, Lipsitch M, Botswana Combination Prevention Project and the PANGEA consortium.|Journal: Elife|PMID:35229714| March 2022
Mathematical models predict that community-wide access to HIV testing-and-treatment can rapidly and substantially reduce new HIV infections. Yet several large…
Author(s): D’Aeth JC, van der Linden MPG, McGee L, de Lencastre H, Turner P, Song JH, Lo SW, Gladstone RA, Sá-Leão R, Ko KS, Hanage WP, Breiman RF, Beall B, Bentley SD, Croucher NJ, GPS Consortium.|Journal: Elife|PMID:34259624| July 2021
Multidrug-resistant emerge through the modification of core genome loci through short inter-species homologous recombinations and acquisition of gene cassettes. Both…
Author(s): Hicks AL, Kissler SM, Mortimer TD, Ma KC, Taiaroa G, Ashcroft M, Williamson DA, Lipsitch M, Grad YH|Journal: Elife|PMID:32602459| June 2020
Genotype-based diagnostics for antibiotic resistance represent a promising alternative to empiric therapy, reducing inappropriate antibiotic use. However, because such assays…
Author(s): Tedijanto C, Grad YH, Lipsitch M|Journal: Elife|PMID:32022685| February 2020
The relationship between antibiotic stewardship and population levels of antibiotic resistance remains unclear. In order to better understand shifts in…