Publications – Center for Communicable Disease Dynamics

Comparison of the test-negative design and cohort design with explicit target trial emulation for evaluating Covid-19 vaccine effectiveness.

Author(s): Li G, Gerlovin H, Figueroa Muñiz MJ, Wise JK, Madenci AL, Robins JM, Aslan M, Cho K, Gaziano JM, Lipsitch M, Casas JP, Hernán MA, Dickerman BAJournal: EpidemiologyPMID: 38109485 March 2024

Observational studies are used for estimating vaccine effectiveness under real-world conditions. The practical performance of two common approaches - cohort…

Estimated excess deaths due to COVID-19 among the urban population of Mainland China, December 2022 to January 2023.

Author(s): Raphson L, Lipsitch MJournal: EpidemiologyPMID: 38300113 January 2024

Mainland China experienced a major surge in SARS-CoV-2 infections in December 2022-January 2023, but its impact on mortality was unclear…

Estimating vaccine efficacy against transmission via effect on viral load.

Author(s): Kennedy-Shaffer L, Kahn R, Lipsitch MJournal: EpidemiologyPMID: 34469363 September 2021

Determining policies to end the SARS-CoV-2 pandemic will require an understanding of the efficacy and effectiveness (hereafter, efficacy) of vaccines.…

Leveraging pathogen sequence and contact tracing data to enhance vaccine trials in emerging epidemics.

Author(s): Kahn R, Wang R, Leavitt SV, Hanage WP, Lipsitch MJournal: EpidemiologyPMID: 34039898 May 2021

Advance planning of vaccine trials conducted during outbreaks increases our ability to rapidly define the efficacy and potential impact of…

Hospitalizations associated with respiratory syncytial virus (RSV) and influenza in children, including children diagnosed with asthma.

Author(s): Goldstein E, Finelli L, O'Halloran A, Liu P, Karaca Z, Steiner CA, Viboud C, Lipsitch MJournal: EpidemiologyPMID: 31469696 November 2019

There is uncertainty about the burden of hospitalization associated with respiratory syncytial virus (RSV) and influenza in children, including those…

The use of test-negative controls to monitor vaccine effectiveness: a systematic review of methodology.

Author(s): Chua H, Feng S, Lewnard JA, Sullivan SG, Blyth CC, Lipsitch M, Cowling BJJournal: EpidemiologyPMID: 31609860 October 2019

The test-negative design is an increasingly popular approach for estimating vaccine effectiveness (VE) due to its efficiency. This review aims…

Temporally Varying Relative Risks for Infectious Diseases: Implications for Infectious Disease Control.

Author(s): Goldstein E, Pitzer VE, O'Hagan JJ, Lipsitch MJournal: EpidemiologyPMID: 27748685 January 2017

Risks for disease in some population groups relative to others (relative risks) are usually considered to be consistent over time,…

Quantifying the impact of accessibility on preventive healthcare in sub-Saharan Africa using mobile phone data.

Author(s): Wesolowski A, O'Meara WP, Tatem AJ, Ndege S, Eagle N, Buckee COJournal: EpidemiologyPMID: 25643101 March 2015

Poor physical access to health facilities has been identified as an important contributor to reduced uptake of preventive health services…

The US 2009 A(H1N1) influenza epidemic: quantifying the impact of school openings on the reproductive number.

Author(s): Huang KE, Lipsitch M, Shaman J, Goldstein EJournal: EpidemiologyPMID: 24434751 March 2014

There is limited information on differences in the dynamics of influenza transmission during time periods when schools are open compared…

Estimating the per-exposure effect of infectious disease interventions.

Author(s): O'Hagan JJ, Lipsitch M, Hernán MAJournal: EpidemiologyPMID: 24240656 January 2014

The average effect of an infectious disease intervention (eg, a vaccine) varies across populations with different degrees of exposure to…