Emergence and evolution of antimicrobial resistance genes and mutations in Neisseria gonorrhoeae

Author(s): Koji Yahara, Kevin C. Ma, Tatum D. Mortimer, Ken Shimuta, Shu-ichi Nakayama, Aki Hirabayashi, Masato Suzuki, Michio Jinnai, Hitomi Ohya, Toshiro Kuroki, Yuko Watanabe, Mitsuru Yasuda, Takashi Deguchi, Vegard Eldholm, Odile B Harrison, Martin C. J. Maiden, Yonatan H. Grad, Makoto OhnishiJournal: bioRxiv October 2020
Antimicrobial resistance in Neisseria gonorrhoeae is a global health concern. Strains from two internationally circulating sequence types, ST-7363 and ST-1901,…

Multiple blood feeding in mosquitoes shortens the Plasmodium falciparum incubation period and increases malaria transmission potential

Author(s): W. Robert Shaw, Inga E. Holmdahl, Maurice A. Itoe, Kristine Werling, Meghan Marquette, Douglas G. Paton, Naresh Singh, Caroline O Buckee, Lauren M. Childs, Flaminia CatterucciaJournal: bioRxiv July 2020
Many mosquito species, including the major malaria vector Anopheles gambiae, naturally undergo multiple reproductive cycles of blood feeding, egg development…

A community-driven resource for genomic surveillance of Neisseria gonorrhoeae at Pathogenwatch

Author(s): Leonor Sánchez-Busó, Corin A. Yeats, Ben Taylor, Richard Goater, Anthony Underwood, Khalil Abudahab, Silvia Argimón, Kevin C. Ma, Tatum D. Mortimer, Michelle J. Cole, Yonatan H. Grad, Irene Martin, Brian H. Raphael, William M. Shafer, Gianfranco Spiteri, Katy Town, Teodora Wi, Simon R. Harris, Magnus Unemo, David M. AanensenJournal: bioRxiv July 2020
Antimicrobial resistant (AMR) Neisseria gonorrhoeae is an urgent threat to public health, as strains resistant to at least one of…

Increased antibiotic susceptibility in Neisseria gonorrhoeae through adaptation to the cervical environment

Author(s): Kevin C. Ma, Tatum D. Mortimer, Allison L Hicks, Nicole E Wheeler, Leonor Sánchez-Busó, Daniel Golparian, George Taiaroa, Daniel HF Rubin, Yi Wang, Deborah A Williamson, Magnus Unemo, Simon R. Harris, Yonatan H. GradJournal: bioRxiv May 2020
Neisseria gonorrhoeae is an urgent public health threat due to rapidly increasing incidence and antibiotic resistance. In contrast with the…

Multimodal memory T cell profiling identifies a reduction in a polyfunctional Th17 state associated with tuberculosis progression

Author(s): Aparna Nathan, Jessica I. Beynor, Yuriy Baglaenko, Sara Suliman, Kazuyoshi Ishigaki, Samira Asgari, Chuan-Chin Huang, Yang Luo, Zibiao Zhang, Kattya Lopez Tamara, Judith Jimenez, Roger I. Calderón, Leonid Lecca, Ildiko van Rhijn, D. Branch Moody, Megan B. Murray, Soumya RaychaudhuriJournal: bioRxiv April 2020
Mycobacterium tuberculosis (M.tb) results in 10 million active tuberculosis (TB) cases and 1.5 million deaths each year, making it the…

Predicting evolution using frequency-dependent selection in bacterial populations

Author(s): Taj Azarian, Pamela P Martinez, Brian J Arnold, Lindsay R Grant, Jukka Corander, Christophe Fraser, Nicholas J. Croucher, Laura L Hammitt, Raymond Reid, Mathuram Santosham, Robert C Weatherholtz, Stephen D Bentley, Katherine L O’Brien, Marc Lipsitch, William P HanageJournal: bioRxiv February 2020
Predicting how pathogen populations will change over time is challenging. Such has been the case with Streptococcus pneumoniae, an important…

Longitudinal analysis of naturally acquired antibodies to PfEMP1 CIDR domain variants and their association with malaria protection

Author(s): Nyamekye Obeng-Adjei, Daniel B Larremore, Louise Turner, Aissata Ongoiba, Shanping Li, Safiatou Doumbo, Takele B. Yazew, Kassoum Kayentao, Louis H. Miller, Boubacar Traore, Susan K. Pierce, Caroline O Buckee, Thomas Lavstsen, Peter D. Crompton, Tuan M. TranJournal: bioRxiv February 2020
Malaria pathogenicity is determined, in part, by the adherence of Plasmodium falciparum infected erythrocytes to the microvasculature mediated via specific…