Publications – Page 13 – Center for Communicable Disease Dynamics

Selective and genetic constraints on pneumococcal serotype switching.

Author(s): Croucher NJ, Kagedan L, Thompson CM, Parkhill J, Bentley SD, Finkelstein JA, Lipsitch M, Hanage WPJournal: PLoS GenetPMID: 25826208 March 2015

Streptococcus pneumoniae isolates typically express one of over 90 immunologically distinguishable polysaccharide capsules (serotypes), which can be classified into "serogroups"…

Functional characterization of bacteria isolated from ancient arctic soil exposes diverse resistance mechanisms to modern antibiotics.

Author(s): Perron GG, Whyte L, Turnbaugh PJ, Goordial J, Hanage WP, Dantas G, Desai MMJournal: PLoS OnePMID: 25807523 March 2015

Using functional metagenomics to study the resistomes of bacterial communities isolated from different layers of the Canadian high Arctic permafrost,…

Antibiotics in agriculture and the risk to human health: how worried should we be?

Author(s): Chang Q, Wang W, Regev-Yochay G, Lipsitch M, Hanage WPJournal: Evol ApplPMID: 25861382 March 2015

The use of antibiotics in agriculture is routinely described as a major contributor to the clinical problem of resistant disease…

Origin and proliferation of multiple-drug resistance in bacterial pathogens.

Author(s): Chang HH, Cohen T, Grad YH, Hanage WP, O'Brien TF, Lipsitch MJournal: Microbiol Mol Biol RevPMID: 25652543 March 2015

Many studies report the high prevalence of multiply drug-resistant (MDR) strains. Because MDR infections are often significantly harder and more…

Stability of the pneumococcal population structure in Massachusetts as PCV13 was introduced.

Author(s): Chang Q, Stevenson AE, Croucher NJ, Lee GM, Pelton SI, Lipsitch M, Finkelstein JA, Hanage WPJournal: BMC Infect DisPMID: 25887323 February 2015

The success of 7-valent pneumococcal conjugate vaccination (PCV-7) introduced to the US childhood immunization schedule in 2000 was partially offset…

The distribution of pairwise genetic distances: a tool for investigating disease transmission.

Author(s): Worby CJ, Chang HH, Hanage WP, Lipsitch MJournal: GeneticsPMID: 25313129 December 2014

Whole-genome sequencing of pathogens has recently been used to investigate disease outbreaks and is likely to play a growing role…

Diversification of bacterial genome content through distinct mechanisms over different timescales.

Author(s): Croucher NJ, Coupland PG, Stevenson AE, Callendrello A, Bentley SD, Hanage WPJournal: Nat CommunPMID: 25407023 November 2014

Bacterial populations often consist of multiple co-circulating lineages. Determining how such population structures arise requires understanding what drives bacterial diversification.…

Microbiology: Microbiome science needs a healthy dose of scepticism.

Author(s): Hanage WPJournal: NaturePMID: 25143098 August 2014

Comprehensive identification of single nucleotide polymorphisms associated with beta-lactam resistance within pneumococcal mosaic genes.

Author(s): Chewapreecha C, Marttinen P, Croucher NJ, Salter SJ, Harris SR, Mather AE, Hanage WP, Goldblatt D, Nosten FH, Turner C, Turner P, Bentley SD, Parkhill JJournal: PLoS GenetPMID: 25101644 August 2014

Traditional genetic association studies are very difficult in bacteria, as the generally limited recombination leads to large linked haplotype blocks,…

Biomedical Ph.D. students enrolled in two elite universities in the United kingdom and the United States report adopting multiple learning relationships.

Author(s): Kemp MW, Lazarus BM, Perron GG, Hanage WP, Chapman EJournal: PLoS OnePMID: 25054473 July 2014

The ability to form multiple learning relationships is a key element of the doctoral learning environment in the biomedical sciences.…