Publications – Page 16 – Center for Communicable Disease Dynamics

Variation at the capsule locus, cps, of mistyped and non-typable Streptococcus pneumoniae isolates.

Author(s): Salter SJ, Hinds J, Gould KA, Lambertsen L, Hanage WP, Antonio M, Turner P, Hermans PW, Bootsma HJ, O'Brien KL, Bentley SDJournal: MicrobiologyPMID: 22403189 June 2012

The capsule polysaccharide locus (cps) is the site of the capsule biosynthesis gene cluster in encapsulated Streptococcus pneumoniae. A set…

Pneumococcal sequence type replacement among American Indian children: a comparison of pre- and routine-PCV7 eras.

Author(s): Scott JR, Hanage WP, Lipsitch M, Millar EV, Moulton LH, Hinds J, Reid R, Santosham M, O'Brien KLJournal: VaccinePMID: 22094283 March 2012

Multi-locus sequence typing (MLST) of pneumococcal isolates collected during an efficacy trial of the 7-valent pneumococcal conjugate vaccine (PCV7) among…

Pneumococcal carriage and antibiotic resistance in young children before 13-valent conjugate vaccine.

Author(s): Wroe PC, Lee GM, Finkelstein JA, Pelton SI, Hanage WP, Lipsitch M, Stevenson AE, Rifas-Shiman SL, Kleinman K, Dutta-Linn MM, Hinrichsen VL, Lakoma M, Huang SSJournal: Pediatr Infect Dis JPMID: 22173142 March 2012

We sought to measure trends in Streptococcus pneumoniae carriage and antibiotic resistance in young children in Massachusetts communities after widespread…

Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011.

Author(s): Grad YH, Lipsitch M, Feldgarden M, Arachchi HM, Cerqueira GC, FitzGerald M, Godfrey P, Haas BJ, Murphy CI, Russ C, Sykes S, Walker BJ, Wortman JR, Young S, Zeng Q, Abouelleil A, Bochicchio J, Chauvin S, Desmet T, Gujja S, McCowan C, Montmayeur A, Steelman S, Frimodt-Møller J, Petersen AM, Struve C, Krogfelt KA, Bingen E, Weill FX, Lander ES, Nusbaum C, Birren BW, Hung DT, Hanage WPJournal: Proc Natl Acad Sci U S APMID: 22315421 February 2012

The degree to which molecular epidemiology reveals information about the sources and transmission patterns of an outbreak depends on the…

Detection of recombination events in bacterial genomes from large population samples.

Author(s): Marttinen P, Hanage WP, Croucher NJ, Connor TR, Harris SR, Bentley SD, Corander JJournal: Nucleic Acids ResPMID: 22064866 January 2012

Analysis of important human pathogen populations is currently under transition toward whole-genome sequencing of growing numbers of samples collected on…

Clonal replacement among 19A Streptococcus pneumoniae in Massachusetts, prior to 13 valent conjugate vaccination.

Author(s): Hanage WP, Bishop CJ, Lee GM, Lipsitch M, Stevenson A, Rifas-Shiman SL, Pelton SI, Huang SS, Finkelstein JAJournal: VaccinePMID: 21964059 November 2011

As part of an ongoing study of the response of the Streptococcus pneumoniae population to conjugate vaccination, we applied multi-locus…

Population biology of Gram-positive pathogens: high-risk clones for dissemination of antibiotic resistance.

Author(s): Willems RJ, Hanage WP, Bessen DE, Feil EJJournal: FEMS Microbiol RevPMID: 21658083 September 2011

Infections caused by multiresistant Gram-positive bacteria represent a major health burden in the community as well as in hospitalized patients.…

High levels of recombination among Streptococcus pneumoniae isolates from the Gambia.

Author(s): Donkor ES, Bishop CJ, Gould K, Hinds J, Antonio M, Wren B, Hanage WPJournal: MBioPMID: 21693638 June 2011

We carried out multilocus sequence typing (MLST) on 148 pneumococcal carriage isolates collected from children <24 months old in the…

Carried pneumococci in Massachusetts children: the contribution of clonal expansion and serotype switching.

Author(s): Hanage WP, Bishop CJ, Huang SS, Stevenson AE, Pelton SI, Lipsitch M, Finkelstein JAJournal: Pediatr Infect Dis JPMID: 21085049 April 2011

Vaccination against 7 serotypes of Streptococcus pneumoniae has led to the near extinction of vaccine serotypes in both disease and…

Rapid pneumococcal evolution in response to clinical interventions.

Author(s): Croucher NJ, Harris SR, Fraser C, Quail MA, Burton J, van der Linden M, McGee L, von Gottberg A, Song JH, Ko KS, Pichon B, Baker S, Parry CM, Lambertsen LM, Shahinas D, Pillai DR, Mitchell TJ, Dougan G, Tomasz A, Klugman KP, Parkhill J, Hanage WP, Bentley SDJournal: SciencePMID: 21273480 January 2011

Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus pneumoniae have previously been confounded by high rates of recombination. Sequencing…