Author(s): Croucher NJ, Finkelstein JA, Pelton SI, Parkhill J, Bentley SD, Lipsitch M, Hanage WP|Journal: Sci Data|PMID:26528397| October 2015
Streptococcus pneumoniae is common nasopharyngeal commensal bacterium and important human pathogen. Vaccines against a subset of pneumococcal antigenic diversity have…
Author(s): Li Y, Croucher NJ, Thompson CM, Trzciński K, Hanage WP, Lipsitch M|Journal: BMC Genomics|PMID:25956132| May 2015
Understanding genetic determinants of a microbial phenotype generally involves creating and comparing isogenic strains differing at the locus of interest,…
Author(s): Croucher NJ, Kagedan L, Thompson CM, Parkhill J, Bentley SD, Finkelstein JA, Lipsitch M, Hanage WP|Journal: PLoS Genet|PMID:25826208| March 2015
Streptococcus pneumoniae isolates typically express one of over 90 immunologically distinguishable polysaccharide capsules (serotypes), which can be classified into "serogroups"…
Author(s): Croucher NJ, Coupland PG, Stevenson AE, Callendrello A, Bentley SD, Hanage WP|Journal: Nat Commun|PMID:25407023| November 2014
Bacterial populations often consist of multiple co-circulating lineages. Determining how such population structures arise requires understanding what drives bacterial diversification.…
Traditional genetic association studies are very difficult in bacteria, as the generally limited recombination leads to large linked haplotype blocks,…
Author(s): Croucher NJ, Hanage WP, Harris SR, McGee L, van der Linden M, de Lencastre H, Sá-Leão R, Song JH, Ko KS, Beall B, Klugman KP, Parkhill J, Tomasz A, Kristinsson KG, Bentley SD|Journal: BMC Biol|PMID:24957517| June 2014
Pneumococcal β-lactam resistance was first detected in Iceland in the late 1980s, and subsequently peaked at almost 25% of clinical…
Whole-genome sequencing of 616 asymptomatically carried Streptococcus pneumoniae isolates was used to study the impact of the 7-valent pneumococcal conjugate…