Publications – Page 2 – Center for Communicable Disease Dynamics

Intrahost Evolution of Methicillin-Resistant Staphylococcus aureus USA300 Among Individuals With Reoccurring Skin and Soft-Tissue Infections.

Author(s): Azarian T, Daum RS, Petty LA, Steinbeck JL, Yin Z, Nolan D, Boyle-Vavra S, Hanage WP, Salemi M, David MZJournal: J Infect DisPMID: 27288537 September 2016

Methicillin-resistant Staphylococcus aureus (MRSA) USA300 is the leading cause of MRSA infections in the United States and has caused an…

Impact of Host Heterogeneity on the Efficacy of Interventions to Reduce Staphylococcus aureus Carriage.

Author(s): Chang Q, Lipsitch M, Hanage WPJournal: Infect Control Hosp EpidemiolPMID: 26598029 February 2016

Staphylococcus aureus is a common cause of bacterial infections worldwide. It is most commonly carried in and transmitted from the…

Interim results of an ecological experiment – Conjugate vaccination against the pneumococcus and serotype replacement.

Author(s): Hausdorff WP, Hanage WPJournal: Hum Vaccin ImmunotherPMID: 26905681 January 2016

Streptococcus pneumoniae has more than 95 serotypes, each of which presumably can cause sepsis, meningitis, pneumonia, and acute otitis media.…

Mechanisms of genome evolution of Streptococcus.

Author(s): Andam CP, Hanage WPJournal: Infect Genet EvolPMID: 25461843 July 2015

The genus Streptococcus contains 104 recognized species, many of which are associated with human or animal hosts. A globally prevalent…

Carriage burden, multiple colonization and antibiotic pressure promote emergence of resistant vaccine escape pneumococci.

Author(s): Mitchell PK, Lipsitch M, Hanage WPJournal: Philos Trans R Soc Lond B Biol SciPMID: 25918447 June 2015

Pneumococcal conjugate vaccines target the limited subset of the more than 90 known serotypes of Streptococcus pneumoniae responsible for the…

Identification of pneumococcal colonization determinants in the stringent response pathway facilitated by genomic diversity.

Author(s): Li Y, Croucher NJ, Thompson CM, Trzciński K, Hanage WP, Lipsitch MJournal: BMC GenomicsPMID: 25956132 May 2015

Understanding genetic determinants of a microbial phenotype generally involves creating and comparing isogenic strains differing at the locus of interest,…

Origin and proliferation of multiple-drug resistance in bacterial pathogens.

Author(s): Chang HH, Cohen T, Grad YH, Hanage WP, O'Brien TF, Lipsitch MJournal: Microbiol Mol Biol RevPMID: 25652543 March 2015

Many studies report the high prevalence of multiply drug-resistant (MDR) strains. Because MDR infections are often significantly harder and more…

Comprehensive identification of single nucleotide polymorphisms associated with beta-lactam resistance within pneumococcal mosaic genes.

Author(s): Chewapreecha C, Marttinen P, Croucher NJ, Salter SJ, Harris SR, Mather AE, Hanage WP, Goldblatt D, Nosten FH, Turner C, Turner P, Bentley SD, Parkhill JJournal: PLoS GenetPMID: 25101644 August 2014

Traditional genetic association studies are very difficult in bacteria, as the generally limited recombination leads to large linked haplotype blocks,…

Genomic epidemiology of Neisseria gonorrhoeae with reduced susceptibility to cefixime in the USA: a retrospective observational study.

Author(s): Grad YH, Kirkcaldy RD, Trees D, Dordel J, Harris SR, Goldstein E, Weinstock H, Parkhill J, Hanage WP, Bentley S, Lipsitch MJournal: Lancet Infect DisPMID: 24462211 March 2014

The emergence of Neisseria gonorrhoeae with decreased susceptibility to extended spectrum cephalosporins raises the prospect of untreatable gonorrhoea. In the…