Publications

The ethics of biosafety considerations in gain-of-function research resulting in the creation of potential pandemic pathogens.

Author(s): Evans NG, Lipsitch M, Levinson M|Journal: J Med Ethics|PMID: 26320212| November 2015

This paper proposes an ethical framework for evaluating biosafety risks of gain-of-function (GOF) experiments that create novel strains of influenza…

The potential impact of coinfection on antimicrobial chemotherapy and drug resistance.

Author(s): Birger RB, Kouyos RD, Cohen T, Griffiths EC, Huijben S, Mina MJ, Volkova V, Grenfell B, Metcalf CJE|Journal: Trends Microbiol|PMID: 26028590| September 2015

Across a range of pathogens, resistance to chemotherapy is a growing problem in both public health and animal health. Despite…

Estimating the hospitalization burden associated with influenza and respiratory syncytial virus in New York City, 2003-2011.

Author(s): Goldstein E, Greene SK, Olson DR, Hanage WP, Lipsitch M|Journal: Influenza Other Respir Viruses|PMID: 25980600| September 2015

Hospitalization burden associated with influenza and respiratory syncytial virus (RSV) is uncertain due to ambiguity in the inference methodologies employed…

Examining the role of different age groups, and of vaccination during the 2012 Minnesota pertussis outbreak.

Author(s): Worby CJ, Kenyon C, Lynfield R, Lipsitch M, Goldstein E|Journal: Sci Rep|PMID: 26278132| August 2015

There is limited information on the roles of different age groups during pertussis outbreaks. Little is known about vaccine effectiveness…

Whole-genome sequencing for national surveillance of Shiga toxin-producing Escherichia coli O157.

Author(s): Dallman TJ, Byrne L, Ashton PM, Cowley LA, Perry NT, Adak G, Petrovska L, Ellis RJ, Elson R, Underwood A, Green J, Hanage WP, Jenkins C, Grant K, Wain J|Journal: Clin Infect Dis|PMID: 25888672| August 2015

National surveillance of gastrointestinal pathogens, such as Shiga toxin-producing Escherichia coli O157 (STEC O157), is key to rapidly identifying linked…

Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae.

Author(s): Watkins ER, Penman BS, Lourenço J, Buckee CO, Maiden MC, Gupta S|Journal: PLoS Pathog|PMID: 26181911| July 2015

The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate vaccines…

Potential Biases in Estimating Absolute and Relative Case-Fatality Risks during Outbreaks.

Author(s): Lipsitch M, Donnelly CA, Fraser C, Blake IM, Cori A, Dorigatti I, Ferguson NM, Garske T, Mills HL, Riley S, Van Kerkhove MD, Hernán MA|Journal: PLoS Negl Trop Dis|PMID: 26181387| July 2015

Estimating the case-fatality risk (CFR)-the probability that a person dies from an infection given that they are a case-is a…

Targeting Human Transmission Biology for Malaria Elimination.

Author(s): Nilsson SK, Childs LM, Buckee C, Marti M|Journal: PLoS Pathog|PMID: 26086192| June 2015

Malaria remains one of the leading causes of death worldwide, despite decades of public health efforts. The recent commitment by…

Carriage burden, multiple colonization and antibiotic pressure promote emergence of resistant vaccine escape pneumococci.

Author(s): Mitchell PK, Lipsitch M, Hanage WP|Journal: Philos Trans R Soc Lond B Biol Sci|PMID: 25918447| June 2015

Pneumococcal conjugate vaccines target the limited subset of the more than 90 known serotypes of Streptococcus pneumoniae responsible for the…

How could preventive therapy affect the prevalence of drug resistance? Causes and consequences.

Author(s): Kunkel A, Colijn C, Lipsitch M, Cohen T|Journal: Philos Trans R Soc Lond B Biol Sci|PMID: 25918446| June 2015

Various forms of preventive and prophylactic antimicrobial therapies have been proposed to combat HIV (e.g. pre-exposure prophylaxis), tuberculosis (e.g. isoniazid…