Publications

Childhood respiratory outpatient visits correlate with socioeconomic status and drive geographic patterns in antibiotic prescribing.

Author(s): Kissler SM, Klevens RM, Barnett ML, Grad YH|Journal: J Infect Dis|PMID: 33903899| April 2021

Reducing geographic disparities in antibiotic prescribing is a central public health priority to combat antibiotic resistance, but the drivers of…

Reduction in antibiotic prescribing attainable with a gonococcal vaccine.

Author(s): Kissler SM, Mitchell M, Grad YH|Journal: Clin Infect Dis|PMID: 33786582| March 2021

We estimated the fraction of antibiotic prescribing in the US attributable to gonorrhea. Gonorrhea contributes to an outsized proportion of…

Estimating SARS-CoV-2 seroprevalence and epidemiological parameters with uncertainty from serological surveys.

Author(s): Larremore DB, Fosdick BK, Bubar KM, Zhang S, Kissler SM, Metcalf CJE, Buckee C, Grad YH|Journal: Elife|PMID: 33666169| March 2021

Establishing how many people have been infected by SARS-CoV-2 remains an urgent priority for controlling the COVID-19 pandemic. Serological tests…

Model-informed COVID-19 vaccine prioritization strategies by age and serostatus.

Author(s): Bubar KM, Reinholt K, Kissler SM, Lipsitch M, Cobey S, Grad YH, Larremore DB|Journal: Science|PMID: 33479118| January 2021

Limited initial supply of SARS-CoV-2 vaccine raises the question of how to prioritize available doses. Here, we used a mathematical…

Large variation in the association between seasonal antibiotic use and resistance across multiple bacterial species and antibiotic classes

Author(s): Sun DS, Kissler SM, Kanjilal S, Olesen SW, Lipsitch M, Grad YH|Journal: medRxiv| December 2020

Understanding how antibiotic use drives resistance is crucial for guiding effective strategies to limit the spread of resistance, but the…

Reductions in commuting mobility correlate with geographic differences in SARS-CoV-2 prevalence in New York City.

Author(s): Kissler SM, Kishore N, Prabhu M, Goffman D, Beilin Y, Landau R, Gyamfi-Bannerman C, Bateman BT, Snyder J, Razavi AS, Katz D, Gal J, Bianco A, Stone J, Larremore D, Buckee CO, Grad YH|Journal: Nat Commun|PMID: 32938924| September 2020

SARS-CoV-2-related mortality and hospitalizations differ substantially between New York City neighborhoods. Mitigation efforts require knowing the extent to which these…

Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants.

Author(s): Hicks AL, Kissler SM, Mortimer TD, Ma KC, Taiaroa G, Ashcroft M, Williamson DA, Lipsitch M, Grad YH|Journal: Elife|PMID: 32602459| June 2020

Genotype-based diagnostics for antibiotic resistance represent a promising alternative to empiric therapy, reducing inappropriate antibiotic use. However, because such assays…

Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period.

Author(s): Kissler SM, Tedijanto C, Goldstein E, Grad YH, Lipsitch M|Journal: Science|PMID: 32291278| May 2020

It is urgent to understand the future of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) transmission. We used estimates of seasonality,…

Distinguishing the roles of antibiotic stewardship and reductions in outpatient visits in generating a five-year decline in antibiotic prescribing.

Author(s): Kissler SM, Klevens RM, Barnett ML, Grad YH|Journal: Clin Infect Dis|PMID: 32173727| March 2020

The mechanisms driving the recent decline in outpatient antibiotic prescribing are unknown. We estimated the extent to which reductions in…

Surveillance to maintain the sensitivity of genotype-based antibiotic resistance diagnostics.

Author(s): Hicks AL, Kissler SM, Lipsitch M, Grad YH|Journal: PLoS Biol|PMID: 31714937| November 2019

The sensitivity of genotype-based diagnostics that predict antimicrobial susceptibility is limited by the extent to which they detect genes and…