Publications

Surveillance strategies for the detection of new SARS-CoV-2 variants across epidemiological contexts

Author(s): Roster KIO, Kissler SM, Omoregie E, Wang JC, Amin H, Lonardo SD, Hughes S, Grad YH|Journal: medRxiv| May 2023

Rapid identification of new SARS-CoV-2 variants is a critical component of the public health response to the COVID-19 pandemic. However,…

A genomic perspective on the near-term impact of doxycycline post-exposure prophylaxis on Neisseria gonorrhoeae antimicrobial resistance.

Author(s): Mortimer TD, Grad YH|Journal: Clin Infect Dis|PMID: 37138444| May 2023

Pre-existing tetracycline resistance in Neisseria gonorrhoeae limits the effectiveness of post-exposure prophylaxis (PEP) with doxycycline against gonorrhea, and selection for…

Resistance and prevalence implications of doxycycline post-exposure prophylaxis for gonorrhea prevention in men who have sex with men: a modeling study.

Author(s): Reichert E, Grad YH|Journal: medRxiv|PMID: 37162882| April 2023

Doxycycline post-exposure prophylaxis (DoxyPEP) has demonstrated efficacy for prevention of bacterial sexually transmitted infections. To inform policy decisions on the…

Projecting the development of antimicrobial resistance in Neisseria gonorrhoeae from antimicrobial surveillance data: a mathematical modelling study.

Author(s): Riou J, Althaus CL, Allen H, Cole MJ, Grad YH, Heijne JCM, Unemo M, Low N|Journal: BMC Infect Dis|PMID: 37081443| April 2023

The World Health Organization recommends changing the first-line antimicrobial treatment for gonorrhoea when ≥ 5% of Neisseria gonorrhoeae cases fail treatment or…

Whole-Genome Sequencing to Predict Antimicrobial Susceptibility Profiles in Neisseria gonorrhoeae.

Author(s): Bristow CC, Mortimer TD, Morris S, Grad YH, Soge OO, Wakatake E, Pascual R, Murphy SM, Fryling KE, Adamson PC, Dillon JA, Parmar NR, Le HHL, Van Le H, Ovalles Ureña RM, Mitchev N, Mlisana K, Wi T, Dickson SP, Klausner JD|Journal: J Infect Dis|PMID: 36735316| April 2023

Neisseria gonorrhoeae is a major public health problem due to increasing incidence and antimicrobial resistance. Genetic markers of reduced susceptibility…

A genomic perspective on the near-term impact of doxycycline post-exposure prophylaxis on Neisseria gonorrhoeae antimicrobial resistance.

Author(s): Mortimer TD, Grad YH|Journal: medRxiv|PMID: 36993406| March 2023

Post-exposure prophylaxis with doxycycline (doxyPEP) is being introduced to prevent bacterial sexually transmitted infections (STIs). Pre-existing tetracycline resistance in limits…

Neisseria gonorrhoeae diagnostic escape from a gyrA-based test for ciprofloxacin susceptibility and the effect on zoliflodacin resistance: a bacterial genetics and experimental evolution study.

Author(s): Rubin DH, Mortimer TD, Grad YH|Journal: Lancet Microbe|PMID: 36868257| February 2023

The aetiological bacterial agent of gonorrhoea, Neisseria gonorrhoeae, has become resistant to each of the first-line antibiotics used to treat…

Resistance-minimizing strategies for introducing a novel antibiotic for gonorrhea treatment: a mathematical modeling study.

Author(s): Reichert E, Yaesoubi R, Rönn MM, Gift TL, Salomon JA, Grad YH|Journal: medRxiv|PMID: 36824857| February 2023

Gonorrhea is a highly prevalent sexually transmitted infection and an urgent public health concern due to increasing antibiotic resistance. Only…

Generating simple classification rules to predict local surges in COVID-19 hospitalizations.

Author(s): Yaesoubi R, You S, Xi Q, Menzies NA, Tuite A, Grad YH, Salomon JA|Journal: Health Care Manag Sci|PMID: 36692583| January 2023

Low rates of vaccination, emergence of novel variants of SARS-CoV-2, and increasing transmission relating to seasonal changes and relaxation of…

CanB is a metabolic mediator of antibiotic resistance in Neisseria gonorrhoeae.

Author(s): Rubin DHF, Ma KC, Westervelt KA, Hullahalli K, Waldor MK, Grad YH|Journal: Nat Microbiol|PMID: 36604513| January 2023

The evolution of the obligate human pathogen Neisseria gonorrhoeae has been shaped by selective pressures from diverse host niche environments…