Author(s): Larremore DB, Sundararaman SA, Liu W, Proto WR, Clauset A, Loy DE, Speede S, Plenderleith LJ, Sharp PM, Hahn BH, Rayner JC, Buckee CO|Journal: Nat Commun|PMID:26456841| October 2015
Antigens encoded by the var gene family are major virulence factors of the human malaria parasite Plasmodium falciparum, exhibiting enormous…
Author(s): Wesolowski A, Metcalf CJ, Eagle N, Kombich J, Grenfell BT, Bjørnstad ON, Lessler J, Tatem AJ, Buckee CO|Journal: Proc Natl Acad Sci U S A|PMID:26283349| September 2015
Changing patterns of human aggregation are thought to drive annual and multiannual outbreaks of infectious diseases, but the paucity of…
Author(s): Watkins ER, Penman BS, Lourenço J, Buckee CO, Maiden MC, Gupta S|Journal: PLoS Pathog|PMID:26181911| July 2015
The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate vaccines…
Author(s): Sheppard SK, Cheng L, Méric G, de Haan CP, Llarena AK, Marttinen P, Vidal A, Ridley A, Clifton-Hadley F, Connor TR, Strachan NJ, Forbes K, Colles FM, Jolley KA, Bentley SD, Maiden MC, Hänninen ML, Parkhill J, Hanage WP, Corander J|Journal: Mol Ecol|PMID:24689900| May 2014
Homologous recombination between bacterial strains is theoretically capable of preventing the separation of daughter clusters, and producing cohesive clouds of…
Acquired immunity to Plasmodium falciparum infection causes a change from frequent, sometimes life-threatening, malaria in young children to asymptomatic, chronic…
Author(s): Willems RJ, Top J, van Schaik W, Leavis H, Bonten M, Sirén J, Hanage WP, Corander J|Journal: MBio|PMID:22807567| July 2012
Enterococcus faecium has recently emerged as an important multiresistant nosocomial pathogen. Defining population structure in this species is required to…
Author(s): Scott JR, Hinds J, Gould KA, Millar EV, Reid R, Santosham M, O'Brien KL, Hanage WP|Journal: J Infect Dis|PMID:22536000| July 2012
Pneumococci could evade pneumococcal conjugate vaccines (PCV) by modifying, mutating, or deleting vaccine-serotype capsule genes or by downregulating capsule production.…
Author(s): Scott JR, Millar EV, Lipsitch M, Moulton LH, Weatherholtz R, Perilla MJ, Jackson DM, Beall B, Craig MJ, Reid R, Santosham M, O'Brien KL|Journal: J Infect Dis|PMID:22128315| January 2012
We assessed the impact of 12 years of pneumococcal conjugate vaccine (PCV7) use on pneumococcal nasopharyngeal carriage and serotype-specific invasive…
