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Publications

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Estimating rates of carriage acquisition and clearance and competitive ability for pneumococcal serotypes in Kenya with a Markov transition model.

Author(s): Lipsitch M, Abdullahi O, DʼAmour A, Xie W, Weinberger DM, Tchetgen Tchetgen E, Scott JA|Journal: Epidemiology|PMID: 22441543| July 2012
There are more than 90 serotypes of Streptococcus pneumoniae, with varying biologic and epidemiologic properties. Animal studies suggest that carriage…

Niche and neutral effects of acquired immunity permit coexistence of pneumococcal serotypes.

Author(s): Cobey S, Lipsitch M|Journal: Science|PMID: 22383809| March 2012
Over 90 capsular serotypes of Streptococcus pneumoniae, a common nasopharyngeal colonizer and major cause of pneumonia, bacteremia, and meningitis, are…

Distinct effects on diversifying selection by two mechanisms of immunity against Streptococcus pneumoniae.

Author(s): Li Y, Gierahn T, Thompson CM, Trzciński K, Ford CB, Croucher N, Gouveia P, Flechtner JB, Malley R, Lipsitch M|Journal: PLoS Pathog|PMID: 23144610| January 2012
Antigenic variation to evade host immunity has long been assumed to be a driving force of diversifying selection in pathogens.…

Serotype replacement in disease after pneumococcal vaccination.

Author(s): Weinberger DM, Malley R, Lipsitch M|Journal: Lancet|PMID: 21492929| December 2011
Vaccination with heptavalent pneumococcal conjugate vaccine (PCV7) has significantly reduced the burden of pneumococcal disease and has had an important…

Prediction of serotypes causing invasive pneumococcal disease in unvaccinated and vaccinated populations.

Author(s): Weinberger DM, Harboe ZB, Flasche S, Scott JA, Lipsitch M|Journal: Epidemiology|PMID: 21646962| March 2011
Before the introduction of the heptavalent pneumococcal conjugate vaccine (Prevnar-7), the relative prevalence of serotypes of Streptococcus pneumoniae was fairly…

Association of serotype with risk of death due to pneumococcal pneumonia: a meta-analysis.

Author(s): Weinberger DM, Harboe ZB, Sanders EA, Ndiritu M, Klugman KP, Rückinger S, Dagan R, Adegbola R, Cutts F, Johnson HL, O'Brien KL, Scott JA, Lipsitch M|Journal: Clin Infect Dis|PMID: 20715907| September 2010
The 92 capsular serotypes of Streptococcus pneumoniae differ greatly in nasopharyngeal carriage prevalence, invasiveness, and disease incidence. There has been…

Re-emergence of the type 1 pilus among Streptococcus pneumoniae isolates in Massachusetts, USA.

Author(s): Regev-Yochay G, Hanage WP, Trzciński K, Rifas-Shiman SL, Lee G, Bessolo A, Huang SS, Pelton SI, McAdam AJ, Finkelstein JA, Lipsitch M, Malley R|Journal: Vaccine|PMID: 20434550| July 2010
Pneumococcal type 1 pilus proteins have been proposed as potential vaccine candidates. Following conjugate pneumococcal vaccination, the prevalence of the…

The role of complement in innate and adaptive immunity to pneumococcal colonization and sepsis in a murine model.

Author(s): Bogaert D, Thompson CM, Trzciński K, Malley R, Lipsitch M|Journal: Vaccine|PMID: 19892042| January 2010
Streptococcus pneumoniae is an important bacterial cause of sepsis, meningitis, pneumonia and otitis media. Pneumococcal disease is generally preceded by…

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