Author(s): Lipsitch M, Abdullahi O, DʼAmour A, Xie W, Weinberger DM, Tchetgen Tchetgen E, Scott JA|Journal: Epidemiology|PMID:22441543| July 2012
There are more than 90 serotypes of Streptococcus pneumoniae, with varying biologic and epidemiologic properties. Animal studies suggest that carriage…
Author(s): Cobey S, Lipsitch M|Journal: Science|PMID:22383809| March 2012
Over 90 capsular serotypes of Streptococcus pneumoniae, a common nasopharyngeal colonizer and major cause of pneumonia, bacteremia, and meningitis, are…
Author(s): Li Y, Gierahn T, Thompson CM, Trzciński K, Ford CB, Croucher N, Gouveia P, Flechtner JB, Malley R, Lipsitch M|Journal: PLoS Pathog|PMID:23144610| January 2012
Antigenic variation to evade host immunity has long been assumed to be a driving force of diversifying selection in pathogens.…
Author(s): Weinberger DM, Malley R, Lipsitch M|Journal: Lancet|PMID:21492929| December 2011
Vaccination with heptavalent pneumococcal conjugate vaccine (PCV7) has significantly reduced the burden of pneumococcal disease and has had an important…
Author(s): Weinberger DM, Harboe ZB, Flasche S, Scott JA, Lipsitch M|Journal: Epidemiology|PMID:21646962| March 2011
Before the introduction of the heptavalent pneumococcal conjugate vaccine (Prevnar-7), the relative prevalence of serotypes of Streptococcus pneumoniae was fairly…
Author(s): Weinberger DM, Harboe ZB, Sanders EA, Ndiritu M, Klugman KP, Rückinger S, Dagan R, Adegbola R, Cutts F, Johnson HL, O'Brien KL, Scott JA, Lipsitch M|Journal: Clin Infect Dis|PMID:20715907| September 2010
The 92 capsular serotypes of Streptococcus pneumoniae differ greatly in nasopharyngeal carriage prevalence, invasiveness, and disease incidence. There has been…
Author(s): Regev-Yochay G, Hanage WP, Trzciński K, Rifas-Shiman SL, Lee G, Bessolo A, Huang SS, Pelton SI, McAdam AJ, Finkelstein JA, Lipsitch M, Malley R|Journal: Vaccine|PMID:20434550| July 2010
Pneumococcal type 1 pilus proteins have been proposed as potential vaccine candidates. Following conjugate pneumococcal vaccination, the prevalence of the…
Author(s): Bogaert D, Thompson CM, Trzciński K, Malley R, Lipsitch M|Journal: Vaccine|PMID:19892042| January 2010
Streptococcus pneumoniae is an important bacterial cause of sepsis, meningitis, pneumonia and otitis media. Pneumococcal disease is generally preceded by…
