Publications

Targeting Human Transmission Biology for Malaria Elimination.

Author(s): Nilsson SK, Childs LM, Buckee C, Marti M|Journal: PLoS Pathog|PMID: 26086192| June 2015

Malaria remains one of the leading causes of death worldwide, despite decades of public health efforts. The recent commitment by…

Carriage burden, multiple colonization and antibiotic pressure promote emergence of resistant vaccine escape pneumococci.

Author(s): Mitchell PK, Lipsitch M, Hanage WP|Journal: Philos Trans R Soc Lond B Biol Sci|PMID: 25918447| June 2015

Pneumococcal conjugate vaccines target the limited subset of the more than 90 known serotypes of Streptococcus pneumoniae responsible for the…

How could preventive therapy affect the prevalence of drug resistance? Causes and consequences.

Author(s): Kunkel A, Colijn C, Lipsitch M, Cohen T|Journal: Philos Trans R Soc Lond B Biol Sci|PMID: 25918446| June 2015

Various forms of preventive and prophylactic antimicrobial therapies have been proposed to combat HIV (e.g. pre-exposure prophylaxis), tuberculosis (e.g. isoniazid…

Ecological Overlap and Horizontal Gene Transfer in Staphylococcus aureus and Staphylococcus epidermidis.

Author(s): Méric G, Miragaia M, de Been M, Yahara K, Pascoe B, Mageiros L, Mikhail J, Harris LG, Wilkinson TS, Rolo J, Lamble S, Bray JE, Jolley KA, Hanage WP, Bowden R, Maiden MC, Mack D, de Lencastre H, Feil EJ, Corander J, Sheppard SK|Journal: Genome Biol Evol|PMID: 25888688| April 2015

The opportunistic pathogens Staphylococcus aureus and Staphylococcus epidermidis represent major causes of severe nosocomial infection, and are associated with high…

Vaccine testing. Ebola and beyond.

Author(s): Lipsitch M, Eyal N, Halloran ME, Hernán MA, Longini IM, Perencevich EN, Grais RF|Journal: Science|PMID: 25838371| April 2015

Measuring the association between artemisinin-based case management and malaria incidence in southern Vietnam, 1991-2010.

Author(s): Peak CM, Thuan PD, Britton A, Nguyen TD, Wolbers M, Thanh NV, Buckee CO, Boni MF|Journal: Am J Trop Med Hyg|PMID: 25667053| April 2015

In addition to being effective, fast-acting, and well tolerated, artemisinin-based combination therapies (ACTs) are able to kill certain transmission stages…

Dissecting the determinants of malaria chronicity: why within-host models struggle to reproduce infection dynamics.

Author(s): Childs LM, Buckee CO|Journal: J R Soc Interface|PMID: 25673299| March 2015

The duration of infection is fundamental to the epidemiological behaviour of any infectious disease, but remains one of the most…

Modelling challenges in context: lessons from malaria, HIV, and tuberculosis.

Author(s): Childs LM, Abuelezam NN, Dye C, Gupta S, Murray MB, Williams BG, Buckee CO|Journal: Epidemics|PMID: 25843394| March 2015

Malaria, HIV, and tuberculosis (TB) collectively account for several million deaths each year, with all three ranking among the top…

Origin and proliferation of multiple-drug resistance in bacterial pathogens.

Author(s): Chang HH, Cohen T, Grad YH, Hanage WP, O'Brien TF, Lipsitch M|Journal: Microbiol Mol Biol Rev|PMID: 25652543| March 2015

Many studies report the high prevalence of multiply drug-resistant (MDR) strains. Because MDR infections are often significantly harder and more…

Sequence tag-based analysis of microbial population dynamics.

Author(s): Abel S, Abel zur Wiesch P, Chang HH, Davis BM, Lipsitch M, Waldor MK|Journal: Nat Methods|PMID: 25599549| March 2015

We describe sequence tag-based analysis of microbial populations (STAMP) for characterization of pathogen population dynamics during infection. STAMP analyzes the…