Publications

Disseminated Gonococcal Infection Complicated by Prosthetic Joint Infection: Case Report and Genomic and Phylogenetic Analysis.

Author(s): Ogbebor O, Mortimer TD, Fryling K, Zhang JJ, Bhanot N, Grad YH|Journal: Open Forum Infect Dis|PMID: 33553473| December 2020

infections have been increasing globally, with prevalence rising across age groups. In this study, we report a case of disseminated…

Loss of function of nitric oxide reductase associated with neisseria gonorrhoeae infection in women

Author(s): Mortimer T.D., Grad YH, Ma KC, Mortimer TD|Journal: Am J Obstet Gynecol| December 2020

Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea, must adapt to the variable selective pressures in the…

The role of “spillover” in antibiotic resistance.

Author(s): Olesen SW, Lipsitch M, Grad YH|Journal: Proc Natl Acad Sci U S A|PMID: 33139558| November 2020

Antibiotic use is a key driver of antibiotic resistance. Understanding the quantitative association between antibiotic use and resulting resistance is…

Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae.

Author(s): Ma KC, Mortimer TD, Duckett MA, Hicks AL, Wheeler NE, Sánchez-Busó L, Grad YH|Journal: Nat Commun|PMID: 33097713| October 2020

The emergence of resistance to azithromycin complicates treatment of Neisseria gonorrhoeae, the etiologic agent of gonorrhea. Substantial azithromycin resistance remains…

Cross-reactive memory T cells and herd immunity to SARS-CoV-2.

Author(s): Lipsitch M, Grad YH, Sette A, Crotty S|Journal: Nat Rev Immunol|PMID: 33024281| October 2020

Immunity is a multifaceted phenomenon. For T cell-mediated memory responses to SARS-CoV-2, it is relevant to consider their impact both…

Using rapid point-of-care tests to inform antibiotic choice to mitigate drug resistance in gonorrhoea.

Author(s): Vegvari C, Grad YH, White PJ, Didelot X, Whittles LK, Scangarella-Oman NE, Mitrani-Gold FS, Dumont E, Perry CR, Gilchrist K, Hossain M, Mortimer TD, Anderson RM, Gardiner D|Journal: Euro Surveill|PMID: 33124551| October 2020

BackgroundThe first cases of extensively drug resistant gonorrhoea were recorded in the United Kingdom in 2018. There is a public…

Reductions in commuting mobility correlate with geographic differences in SARS-CoV-2 prevalence in New York City.

Author(s): Kissler SM, Kishore N, Prabhu M, Goffman D, Beilin Y, Landau R, Gyamfi-Bannerman C, Bateman BT, Snyder J, Razavi AS, Katz D, Gal J, Bianco A, Stone J, Larremore D, Buckee CO, Grad YH|Journal: Nat Commun|PMID: 32938924| September 2020

SARS-CoV-2-related mortality and hospitalizations differ substantially between New York City neighborhoods. Mitigation efforts require knowing the extent to which these…

Potential Biases Arising from Epidemic Dynamics in Observational Seroprotection Studies.

Author(s): Kahn R, Kennedy-Shaffer L, Grad YH, Robins JM, Lipsitch M|Journal: Am J Epidemiol|PMID: 32870977| September 2020

The extent and duration of immunity following SARS-CoV-2 infection are critical outstanding questions about the epidemiology of this novel virus,…

Efflux Pump Antibiotic Binding Site Mutations Are Associated with Azithromycin Nonsusceptibility in Clinical Neisseria gonorrhoeae Isolates.

Author(s): Ma KC, Mortimer TD, Grad YH|Journal: MBio|PMID: 32843551| August 2020

Lyu and Moseng et al. used cryo-electron microscopy to characterize key residues involved in drug binding by mosaic-like MtrD efflux…

The distribution and spread of susceptible and resistant Neisseria gonorrhoeae across demographic groups in a major metropolitan center.

Author(s): Mortimer TD, Pathela P, Crawley A, Rakeman JL, Lin Y, Harris SR, Blank S, Schillinger JA, Grad YH|Journal: Clin Infect Dis|PMID: 32829411| August 2020

Genomic epidemiology studies of gonorrhea in the United States have primarily focused on national surveillance for antibiotic resistance, and patterns…