Preventing and Predicting Infectious Diseases

In an era when an infected person or vector can cross the world in a day, preventing and containing outbreaks of disease anywhere protects the health of people everywhere. Every large infectious disease threat begins as one or a few cases and becomes widespread only because containment efforts were not tried or did not succeed. Our research enhances preparedness to enable rapid, rational and effective countermeasures to control the spread…

Quantifying and Controlling Infectious Diseases

Quantifying infectious disease threats is the first step toward controlling and eliminating them. Thousands of reports of possible infectious disease outbreaks are produced every month around the world, creating an urgent need to prioritize responses to those threats that are most pressing. Accurate measurement of the number of persons affected, their demographics, the transmissibility and severity of the infection, and the likely variation of these quantities over space and time…

Harnessing Pathogen Evolution

Infectious agents – bacteria, viruses and parasites – evolve in response to selective pressures created by our immune systems, vaccine deployment, and antimicrobial drugs. The resulting genetic changes in the pathogens often have direct consequences for human health – most prominently, antibiotic resistance, but also ongoing transmission of pathogens that have evolved to evade our natural or vaccine-induced immune responses. Understanding the mechanisms by which this selection happens offers the…