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Hsiao-Han Chang

Harvard School of Public Health

Postdoctoral Research Fellow

Epidemiology

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Hsiao-Han Chang is a postdoctoral research fellow at the Harvard School of Public Health working with Marc Lipsitch and Caroline Buckee. Before coming to the center, Hsiao-Han was at the department of Organismic and Evolutionary Biology at Harvard University, where she obtained her PhD with Daniel Hartl and John Wakeley. Her doctoral research focused on genomic variation and evolution of the human malaria parasite Plasmodium falciparum. She will be working on drug resistance evolution and population dynamics and evolution of the malaria parasites by incorporating population genetic tools and epidemiologic data.

Recurrent bottlenecks in the malaria life cycle obscure signals of positive selection.

Chang HH, Hartl DL.

Detecting signals of selection in the genome of malaria parasites is a key to identify targets for drug and vaccine development. Malaria parasites have a unique life cycle alternating between vector and host organism with a population bottleneck at e... (more »).

Parasitology.   2014 Feb.

Research areas: malaria

Malaria life cycle intensifies both natural selection and random genetic drift.

Chang HH, Moss EL, Park DJ, Ndiaye D, Mboup S, Volkman SK, Sabeti PC, Wirth DF, Neafsey DE, Hartl DL.

Analysis of genome sequences of 159 isolates of Plasmodium falciparum from Senegal yields an extraordinarily high proportion (26.85%) of protein-coding genes with the ratio of nonsynonymous to synonymous polymorphism greater than one. This proportion... (more »).

Proc Natl Acad Sci U S A.   2013 Dec. 110 (50): 20129-34.  

Research areas: malaria

The evolution and functional significance of nested gene structures in Drosophila melanogaster.

Lee YC, Chang HH.

Nearly 10% of the genes in the genome of Drosophila melanogaster are in nested structures, in which one gene is completely nested within the intron of another gene (nested and including... (more »).

Genome Biol Evol.   2013 Sep. 5 (10): 1978-85.  

Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal.

Daniels R, Chang HH, Séne PD, Park DC, Neafsey DE, Schaffner SF, Hamilton EJ, Lukens AK, Van Tyne D, Mboup S, Sabeti PC, Ndiaye D, Wirth DF, Hartl DL, Volkman SK.

Using parasite genotyping tools, we screened patients with mild uncomplicated malaria seeking treatment at a clinic in Thiès, Senegal, from 2006 to 2011. We identified a growing frequency of infections caused by genetically iden... (more »).

PLoS One.   2013 Apr. 8 (4): e60780.  

Research areas: malaria

Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population.

Chang HH, Park DJ, Galinsky KJ, Schaffner SF, Ndiaye D, Ndir O, Mboup S, Wiegand RC, Volkman SK, Sabeti PC, Wirth DF, Neafsey DE, Hartl DL.

Malaria is a deadly disease that causes nearly one million deaths each year. To develop methods to control and eradicate malaria, it is important to understand the genetic basis of Plasmodium falciparum adaptations to antimal... (more »).

Mol Biol Evol.   2012 Nov. 29 (11): 3427-39.  

Research areas: malaria

Population Genetics and Parasite Diversity

Chang HH, Daniels RF, Hartl DL.

In Sibley LD, Howlett BJ, and Heitman J, Evolution of Virulence in Eukaryotic Microbes.... (more »).

Wiley-Blackwell. (Book chapter)   2012 Oct.

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite.

Park DJ, Lukens AK, Neafsey DE, Schaffner SF, Chang HH, Valim C, Ribacke U, Van Tyne D, Galinsky K, Galligan M, Becker JS, Ndiaye D, Mboup S, Wiegand RC, Hartl DL, Sabeti PC, Wirth DF, Volkman SK.

Through rapid genetic adaptation and natural selection, the Plasmodium falciparum parasite--the deadliest of those that cause malaria--is able to develop resistance to antimalarial drugs, thwarting present efforts t... (more »).

Proc Natl Acad Sci U S A.   2012 Aug. 13052-7.  

Research areas: malaria