Author(s): Kunkel A, Colijn C, Lipsitch M, Cohen T|Journal: Philos Trans R Soc Lond B Biol Sci|PMID:25918446| June 2015
Various forms of preventive and prophylactic antimicrobial therapies have been proposed to combat HIV (e.g. pre-exposure prophylaxis), tuberculosis (e.g. isoniazid…
Author(s): Li Y, Croucher NJ, Thompson CM, Trzciński K, Hanage WP, Lipsitch M|Journal: BMC Genomics|PMID:25956132| May 2015
Understanding genetic determinants of a microbial phenotype generally involves creating and comparing isogenic strains differing at the locus of interest,…
Author(s): Méric G, Miragaia M, de Been M, Yahara K, Pascoe B, Mageiros L, Mikhail J, Harris LG, Wilkinson TS, Rolo J, Lamble S, Bray JE, Jolley KA, Hanage WP, Bowden R, Maiden MC, Mack D, de Lencastre H, Feil EJ, Corander J, Sheppard SK|Journal: Genome Biol Evol|PMID:25888688| April 2015
The opportunistic pathogens Staphylococcus aureus and Staphylococcus epidermidis represent major causes of severe nosocomial infection, and are associated with high…
Author(s): Peak CM, Thuan PD, Britton A, Nguyen TD, Wolbers M, Thanh NV, Buckee CO, Boni MF|Journal: Am J Trop Med Hyg|PMID:25667053| April 2015
In addition to being effective, fast-acting, and well tolerated, artemisinin-based combination therapies (ACTs) are able to kill certain transmission stages…
Author(s): Croucher NJ, Kagedan L, Thompson CM, Parkhill J, Bentley SD, Finkelstein JA, Lipsitch M, Hanage WP|Journal: PLoS Genet|PMID:25826208| March 2015
Streptococcus pneumoniae isolates typically express one of over 90 immunologically distinguishable polysaccharide capsules (serotypes), which can be classified into "serogroups"…
Author(s): Yang W, Lipsitch M, Shaman J|Journal: Proc Natl Acad Sci U S A|PMID:25730851| March 2015
The inference of key infectious disease epidemiological parameters is critical for characterizing disease spread and devising prevention and containment measures.…
